Gamma-ray Bursts (GRBs) are among the most powerful objects in the Universe. Yet since their discovery over 50 years ago, GRBs have posed numerous theoretical and observational challenges to astrophysicists and have generated a deeper understanding of relativistic phenomena. In this seminar, I will discuss the role of GRBs in multi-messenger astronomy, with a special focus on the future impact of joint observations with gravitational waves. I will also review recent detections of very high energy (>100 GeV) emission from GRBs and how they have both answered long-sought questions about GRB radiation mechanisms and posed new ones. Finally, I will present the surprising observations of two GRBs that imply the historical standard for GRB classification may no longer hold true.