We promote the hybrid kT-factorization formula, for which one initial-state parton momentum is space-like and carries non-vanishing transverse components while the other is on-shell, to NLO. Studying the partonic cross section, we identify all soft and collinear divergencies, and recognize that all non-cancelling ones can be attributed to PDF evolution, evolution kernel, and target impact factors. Furthermore, we construct a framework that may be used to compute NLO impact factors in general, and in particular, we recover known expressions for inclusive NLO quark-and gluon impact factor corrections.