Recent results from LHCb and B-factories hint at violation of Lepton Flavor Universality (LFU) in both charged and neutral B-meson decays. We start by discussing the impact of the new observation of the $\Lambda_b to Lambda_c \tau \nu$ decay on these anomalies and the perspectives it offers in terms of new observables that can be extracted from angular distributions. We will then compare those low energy observables to the constraints that can be obtained from the Drell-Yan processes pp->lnu and pp->ll at high transverse momentum, both in the framework of Effective Field Theory and with explicit O(1 TeV) Leptoquark Mediators.